New internship @calixDNA

C. Thouzé

On April 26th, 2021, calixDNA team is joined by a new student, Corentin Thouzé, who will perform a 16-weeks long internship at our project (until Aug. 13th, 2021). Corentin is a student at the ENSICAEN (Ecole Nationale Superieure de Caen). During his internship at the Ruđer Bošković Institute, he will be working on the recognition and binding studies of the genZ supramolecular biomimetic binders (in particular, calixarene ligand AB118 and its copper(II) complex), as well as on the preliminary determination of the crystallization conditions of several genz SBB ligands and complexes.

2nd project team meeting

CalixDNA project team has had today, scheduled at 11:00 sharp, its second online meeting, with participation of B. Colasson, I. Piantanida, O. Reinaud, and A. Višnjevac (in alphabetical order). Students Ivona Krošl (PhD) and Ena Otković (MS) joined the meeting briefly. Exciting results obtained by experiments of DNA/RNA recognition and binding of our supramolecular biomimetic binders (SBBs), during the first month were extensively discussed. The results were presented by I. Piantanida, and discussion followed. MS student Ena Otković is successfully performing these experiments in frame of her MS thesis, under the supervision of I. Piantanida and direct mentorship of Ivona Krošl. The issue of the timely procurement of calixarene ligands (SBBs) for further recognition/binding studies, as well as for crystallization experiments, was approached. In order to secure the timely delivery of necessary compounds (SBBs), I. Piantanida proposed an establishment of a new collaboration of the project team with the team of synthetic chemists at the Ruđer Bošković Institute with a relevant experience in calixarene synthesis, which was unanimously accepted. The time bridge shall be hence created until the project team is officially joined by a PhD student who will be in charge of the SBB syntheses and shall presumably join the team by the end of 2021. Main focus in this phase, as envisaged by the work plan, will continue to be on recognition and binding studies, of the chosen set of SBBs which were previously delivered from the French partners, including the compound for which recently the single crystal X-ray structure has been determined [Cu(II) complex of the TMPA capped calix[6]arene]. The team working at the recognition and binding studies shall be joined, from April 26th, 2021, by the French intern Correntin Thouze, who will work on the calixDNA project at the Ruđer Bošković Institute in Zagreb, for the duration of three months (until August 2021). The meeting ended at 11:55 h.

Job offer: PostDoc@calixDNA

calixDNA project has launched today a job offer for a postdoctoral fellow who is to join the project team at IRB in Zagreb for a limited duration of 24 months, starting with Aug. 1st, 2021, where he/she will work on a specific problem pertaining to: (i) recognition and binding studies of supramolecular biomimetic calixarene- and resorcinarene-based binders (SBB) to oligonucleotide chains, and (ii) crystallization of biocomplexes SBB-oligonucleotide chains. Engagement in the educational and administrative aspects of the project will also be required. The offer is open until March 12th, 2021, at 10:59 PM, Zagreb time.

For more on the position offered, including the details on how to apply, please follow this link.

First Master student

Ena Otković, second year student of Graduate studies in chemistry at the Faculty of Science, University of Zagreb joined the calixDNA team on Feb. 1st, 2021. Within the calixDNA project, Ena is working on her master’s degree on the study of noncovalent interactions between supramolecular binders of the zero generation (genZ SBBs) and polynucleotide chains, using different spectroscopic techniques.

BSc/MSc thesis at calixDNA

We are looking for motivated students interested in joining our international calixDNA team in frame of their BSc or MSc theses. An ideal candidate would be a student of chemistry or biochemistry, with a strong interest in structural features of the biologically relevant molecules, as well as biological macromolecules. We offer two positions: one in the field of the recognition and binding studies of our supramolecular biomimetic binders (SBBs) to the oligonucleotide chains, and the other pertaining to the crystallization of the water soluble genZ SBBs by use of the macromolecular crystallization techniques. Experimental work will be organized at the Ruđer Bošković Institute in Zagreb, Bijenička c. 54. Crystallization experiments may require short research visits to the Institute of molecular biosciences in Graz, Austria, where the crystallization robot is made available for the calixDNA team members.

The project commences on Feb. 1st, 2021, and so may your experimental work. Please visit for all the details you may be interested in. Should you have any further inquiries, there is a contact form on the website, through which you can reach out. We would be delighted to welcome you on board calixDNA project.

Online kick-off meeting

Members of the calixDNA project team have held on Friday, Dec. 11th, 2020, an online kick-off meeting well ahead the official project start date (Feb. 1st, 2021). The meeting was led by A. Višnjevac, with all team members (Reinaud, Piantanida, Kojić-Prodić and Colasson) participating. Important matters like delivery of the genZ SBBs to be subjected to the binding studies in Piantanida lab, purchase procedures, hiring a postdoc and PhD student etc. were discussed.

calixDNA funded

The Executive board of the Croatian Science Foundation has decided to accept the research project proposal entitled “Biomimetic “funnel” and “bowl” supramolecular systems for the selective recognition of DNA/RNA” or, by its acronyme, “calixDNA” for funding. The proposal was submitted on Feb, 20th, 2020, in frame of the IP-2020-02 call . Research activities are to commence on Feb. 1st, 2021, and to be concluded by Jan. 31st, 2025.